Anticancer activity of a Gold(I) phosphine thioredoxin reductase inhibitor in multiple myeloma.

ABSTRACT: Multiple myeloma (MM), the second most common haematological malignancy, is a clonal plasma B-cell neoplasm that forms within the bone marrow. Despite recent advancements in treatment, MM remains an incurable disease. Auranofin, a linear gold(I) phosphine compound, has previously been shown to exert a significant anti-myeloma activity by inhibiting thioredoxin reductase (TrxR) activity. A bis-chelated tetrahedral gold(I) phosphine complex [Au(d2pype)₂]Cl (where d2pype is 1,2-bis(di-2-pyridylphosphino)ethane) was previously designed to improve the gold(I) compound selectivity towards selenol- and thiol-containing proteins, such as TrxR. In this study, we show that [Au(d2pype)₂]Cl significantly inhibited TrxR activity in both bortezomib-sensitive and resistant myeloma c

SUBMITTER: Sze JH 

PROVIDER: S-EPMC6742860 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature