Computational Assessment of the Pharmacological Profiles of Degradation Products of Chitosan.

ABSTRACT: Chitosan is a natural polymer revealing an increased potential to be used in different biomedical applications, including drug delivery systems, and tissue engineering. It implies the evaluation of the organism response to the biomaterial implantation. Low-molecular degradation products, the chito-oligomers, are resulting mainly from the influence of enzymes, which are found in the organism fluids. Within this study, we have performed the computational assessment of pharmacological profiles and toxicological effects on human health of small chito-oligomers with distinct molecular weights, deacetylation degrees, and acetylation patterns. Our approach is based on the fact that regulatory agencies and researchers in the drug development field rely on the use of modeling to predict biological

SUBMITTER: Roman DL 

PROVIDER: S-EPMC6743017 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature