A biodegradable synthetic graft for small arteries matches the performance of autologous vein in rat carotid arteries.

ABSTRACT: Autologous veins are the most widely used grafts for bypassing small arteries in coronary and peripheral arterial occlusive diseases. However, they have limited availability and cause donor-site morbidity. Here, we report a direct comparison of acellular biodegradable synthetic grafts and autologous veins as interposition grafts of rat carotid arteries, which is a good model for clinically relevant small arteries. Notably, extensive but transient infiltration of circulating monocytes at day 14 in synthetic grafts leads to a quickly-resolved inflammation and arterial-like tissue remodeling. The vein graft exhibits a similar inflammation phase except the prolonged presence of inflammatory monocytes. The walls of the remodeled synthetic graft contain many circumferentially aligned contractile

SUBMITTER: Lee KW 

PROVIDER: S-EPMC6743079 | biostudies-literature | 2018 Oct

REPOSITORIES: biostudies-literature