Additional common variants associated with type 2 diabetes and coronary artery disease detected using a pleiotropic cFDR method.

ABSTRACT: Genome-wide association studies (GWASs) have been performed extensively in diverse populations to identify single nucleotide polymorphisms (SNPs) associated with complex diseases or traits. However, to date, the SNPs identified fail to explain a large proportion of the variance of the traits/diseases. GWASs on type 2 diabetes (T2D) and coronary artery disease (CARD) are generally performed as single-trait studies, rather than analyzing the related traits simultaneously. Despite the extensive evidence suggesting that these two phenotypes share both genetic and environmental risk factors, the shared overlapping genetic biological mechanisms between these traits remain largely unexplored. Here, we adopted a recently developed genetic pleiotropic conditional false discovery rate (cFDR) approac

SUBMITTER: Zhang Q 

PROVIDER: S-EPMC6743331 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature