Central-spindle microtubules are strongly coupled to chromosomes during both anaphase A and anaphase B.

ABSTRACT: Spindle microtubules, whose dynamics vary over time and at different locations, cooperatively drive chromosome segregation. Measurements of microtubule dynamics and spindle ultrastructure can provide insight into the behaviors of microtubules, helping elucidate the mechanism of chromosome segregation. Much work has focused on the dynamics and organization of kinetochore microtubules, that is, on the region between chromosomes and poles. In comparison, microtubules in the central-spindle region, between segregating chromosomes, have been less thoroughly characterized. Here, we report measurements of the movement of central-spindle microtubules during chromosome segregation in human mitotic spindles and Caenorhabditis elegans mitotic and female meiotic spindles. We found that these ce

SUBMITTER: Yu CH 

PROVIDER: S-EPMC6743361 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature