Dimethylethanolamine Decreases Epileptiform Activity in Acute Human Hippocampal Slices in vitro.

ABSTRACT: Temporal lobe epilepsy (TLE) is the most common form of focal epilepsy with about 30% of patients developing pharmacoresistance. These patients continue to suffer from seizures despite polytherapy with antiepileptic drugs (AEDs) and have an increased risk for premature death, thus requiring further efforts for the development of new antiepileptic therapies. The molecule dimethylethanolamine (DMEA) has been tested as a potential treatment in various neurological diseases, albeit the functional mechanism of action was never fully understood. In this study, we investigated the effects of DMEA on neuronal activity in single-cell recordings of primary neuronal cultures. DMEA decreased the frequency of spontaneous synaptic events in a concentration-dependent manner with no apparent effect on res

SUBMITTER: Kraus L 

PROVIDER: S-EPMC6743366 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature