Identification of a mitofusin specificity region that confers unique activities to Mfn1 and Mfn2.

ABSTRACT: Mitochondrial structure can be maintained at steady state or modified in response to changes in cellular physiology. This is achieved by the coordinated regulation of dynamic properties including mitochondrial fusion, division, and transport. Disease states, including neurodegeneration, are associated with defects in these processes. In vertebrates, two mitofusin paralogues, Mfn1 and Mfn2, are required for efficient mitochondrial fusion. The mitofusins share a high degree of homology and have very similar domain architecture, including an amino terminal GTPase domain and two extended helical bundles that are connected by flexible regions. Mfn1 and Mfn2 are nonredundant and are both required for mitochondrial outer membrane fusion. However, the molecular features that make these proteins fu

SUBMITTER: Sloat SR 

PROVIDER: S-EPMC6743458 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature