From basic researches to new achievements in therapeutic strategies of KRAS-driven cancers.

ABSTRACT: Among the numerous oncogenes involved in human cancers, KRAS represents the most studied and best characterized cancer-related genes. Several therapeutic strategies targeting oncogenic KRAS (KRAS ^onc ) signaling pathways have been suggested, including the inhibition of synthetic lethal interactions, direct inhibition of KRAS ^onc itself, blockade of downstream KRAS ^onc effectors, prevention of post-translational KRAS ^onc modifications, inhibition of the induced stem cell-like program, targeting of metabolic peculiarities, stimulation of the immune system, inhibition of inflammation, blockade of upstream signaling pathways, targeted RNA replacement, and oncogene-induced senescence. Despite intensive and continuous effort

SUBMITTER: Saliani M 

PROVIDER: S-EPMC6743616 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature