Borderline personality disorder, trauma, and the hypothalamus-pituitary-adrenal axis.

ABSTRACT: Borderline personality disorder (BPD) is a complex psychiatric illness for which treatment poses a significant challenge due to limited effective pharmacologic treatments, and under-resourced psychological interventions. BPD is one of the most stigmatized conditions in psychiatry today, but can be understood as a modifiable, neurodevelopmental disorder that arises from maladaptive responses to trauma and stress. Stress susceptibility and reactivity in BPD is thought to mediate both the development and maintenance of BPD symptomatology, with trauma exposure considered an early life risk factor of development, and acute stress moderating symptom trajectory. An altered stress response has been characterized in BPD at the structural, neural, and neurobiological level, and is believed to underl

SUBMITTER: Thomas N 

PROVIDER: S-EPMC6743631 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature