The COPD multi-dimensional phenotype: A new classification from the STORICO Italian observational study.

ABSTRACT:

Background

This paper is aimed to (i) develop an innovative classification of COPD, multi-dimensional phenotype, based on a multidimensional assessment; (ii) describe the identified multi-dimensional phenotypes.

Methods

An exploratory factor analysis to identify the main classificatory variables and, then, a cluster analysis based on these variables were run to classify the COPD-diagnosed 514 patients enrolled in the STORICO (trial registration number: NCT03105999) study into multi-dimensional phenotypes.

Results

The circadian rhythm of symptoms and health-related quality of life, but neither comorbidity nor respiratory function, qualified as primary classificatory variables. Five multidimensional phenotypes were identified: the MILD COPD characterized by no night-tim

SUBMITTER: Antonelli Incalzi R 

PROVIDER: S-EPMC6743765 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature