[Expression of NUF2 in breast cancer and its clinical significance].

ABSTRACT:

Objective

To investigate the expression of the cell division- associated gene NUF2 in breast cancer and its clinical significance.

Methods

The expression of NUF2 in breast cancer tissues was analyzed using Oncomine database. The relationship between the expression of NUF2 and the prognosis of breast cancer was analyzed using the Kaplan-Meier Plotter database. Gene set enrichment analysis (GSEA) and GEO database were used to investigate the effect of NUF2 on gene enrichment. The String database was utilized to analyze the proteins associated with NUF2. The TIMER database was analyzed to assess the correlations of NUF2 with BUB1, MAD2L1 and MYC. The expressions of NUF2 mRNA in 8 pairs of breast cancer tissues and adjacent tissues were verified by q-PCR.

Results

Compared

SUBMITTER: Sun J 

PROVIDER: S-EPMC6743945 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature