Antithrombotic Strategies After Bioprosthetic Aortic Valve Replacement: A Systematic Review.

ABSTRACT:

Background

The optimal antithrombotic regimen after bioprosthetic aortic valve replacement (bAVR) is unclear. We conducted a systematic review of various anticoagulation strategies following surgical or transcatheter bAVR (TAVR).

Methods

We searched Medline, PubMed, Embase, Evidence-Based Medicine Reviews, and gray literature through June 2017 for controlled clinical trials and cohort studies that directly compared different antithrombotic strategies in nonpregnant adults who had undergone bAVR. We assessed risk of bias and graded the strength of the evidence using established methods.

Results

Of 4,554 titles reviewed, 6 clinical trials and 13 cohort studies met inclusion criteria. We found moderate-strength evidence that mortality, thromboembolic events, and bleeding

SUBMITTER: Papak JN 

PROVIDER: S-EPMC6743973 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature