[OAS1 gene polymorphism is associated with central nervous system involvement in children with enterovirus 71 infection].

ABSTRACT:

Objective

We investigated the association between OAS1 gene polymorphism and susceptibility to central nervous system (CNS) involvement of enterovirus (EV)71 infection.

Methods

This case-control study was conducted among 180 children with EV71 infection, including 72 with mild infections without any complications and 108 with severe infections and CNS involvement; 201 children undergoing routine physical examination served as the healthy controls. For all the participants, the single nucleotide polymorphisms (SNPs) at OAS1 rs2660 and rs1131454 were analyzed using SNPscan multiple SNP typing methods.

Results

No significant differences were found between the case and control groups in genotype or allele distributions of rs2660 and rs1131454. OAS1 rs

SUBMITTER: Yaping LI 

PROVIDER: S-EPMC6744003 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature