[Efficiency of 27-plex single nucleotide polymorphism multiplex system for ancestry inference in different populations].

ABSTRACT:

Objective

To validate the efficiency of 27-plex single nucleotide polymorphism (SNP) multiplex system for ancestry inference.

Methods

The 27-plex SNP system was validated for its sensitivity and species specificity. A total of 533 samples were collected from African, Southern Chinese Han, China's ethic minorities (Yi, Hui, Miao, Tibet, and Uygur), European, Central Asian, Western Asian, Southern Asian, Southeast Asian and South American populations for clustering analysis of the genotypes by citing 3 representative continental ancestral groups [East Asia (CHB), Europe (CEU), and Africa (YRI)] from HapMap database.

Results

The system sensitivity is 0.125 ng. Twenty and six genotypes were detected in chimpanzee and monkeys, respectively. Except in rs10496971, no more pr

SUBMITTER: Feng XL 

PROVIDER: S-EPMC6744106 | biostudies-literature | 2016 Apr

REPOSITORIES: biostudies-literature