The alternative regenerative strategy of bearded dragon unveils the key processes underlying vertebrate tooth renewal.

ABSTRACT: Deep understanding of tooth regeneration is hampered by the lack of lifelong replacing oral dentition in most conventional models. Here, we show that the bearded dragon, one of the rare vertebrate species with both polyphyodont and monophyodont teeth, constitutes a key model for filling this gap, allowing direct comparison of extreme dentition types. Our developmental and high-throughput transcriptomic data of microdissected dental cells unveils the critical importance of successional dental lamina patterning, in addition to maintenance, for vertebrate tooth renewal. This patterning process happens at various levels, including directional growth but also gene expression levels, dynamics, and regionalization, and involves a large number of yet uncharacterized dental genes. Furthermore, the

SUBMITTER: Salomies L 

PROVIDER: S-EPMC6744223 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature