Electrical stimulation in a spiking neural network model of monkey superior colliculus.

ABSTRACT: The superior colliculus (SC) generates saccades by recruiting a population of cells in its topographically organized motor map. Supra-threshold electrical stimulation in the SC produces a normometric saccade with little effect of the stimulation parameters. Moreover, the kinematics of electrically evoked saccades strongly resemble natural, visual-evoked saccades. These findings support models in which the saccade vector is determined by a center-of-gravity computation of activated neurons, while trajectory and kinematics arise in brainstem-cerebellar feedback circuits. Recent single-unit recordings, however, have indicated that the SC population also specifies the instantaneous saccade kinematics, supporting an alternative model, in which the saccade trajectory results from dynamic summati

SUBMITTER: van Opstal AJ 

PROVIDER: S-EPMC6744279 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature