¹⁸ F-NaF PET/CT IMAGING IN FIBROUS DYSPLASIA OF BONE.

ABSTRACT: Fibrous dysplasia (FD) is a mosaic skeletal disorder resulting in fractures, deformity, and functional impairment. Clinical evaluation has been limited by a lack of surrogate endpoints capable of quantitating disease activity. The purpose of this study was to investigate the utility of ¹⁸ F-NaF PET/CT imaging in quantifying disease activity in patients with FD. Fifteen consecutively evaluated subjects underwent whole-body ¹⁸ F-NaF PET/CT scans, and FD burden was assessed by quantifying FD-related ¹⁸ F-NaF activity. ¹⁸ F-NaF PET/CT parameters obtained included (i) SUV_max (standardized uptake value [SUV] of the FD lesion with the highest uptake); (ii) SUV_mean (average SUV of all ¹⁸ F-NaF-positive FD lesions); (iii)

SUBMITTER: Papadakis GZ 

PROVIDER: S-EPMC6744316 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature