Priapism, hemoglobin desaturation, and red blood cell adhesion in men with sickle cell anemia.

ABSTRACT: Priapism is a serious, but episodic, complication of sickle cell disease (SCD). We had previously reported that subjects with SCD had variable red blood cell (RBC) adhesion to the immobilized sub-endothelial protein laminin (LN). We examined adhesion to LN in a microfluidic device, of RBCs from men with homozygous sickle cell anemia. Adhesion under hypoxic, but not ambient, conditions was greater in men with a history of priapism, with median adhesion of 529 RBCs per 32 mm²/unit area (range 5-5248) rising to 3268 RBCs per 32 mm²/unit area (range 49-18,368, P = 0.004), under ambient and hypoxic conditions, respectively (n = 14). This was not seen in RBCs from men without a history of priapism (median 402 (range 14-785) and 122 (range 31-4112) RBCs per 32 mm²

SUBMITTER: Yuan C 

PROVIDER: S-EPMC6744332 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature