Remission in Crohn's disease is accompanied by alterations in the gut microbiota and mucins production.

ABSTRACT: Previous studies have demonstrated that patients with Crohn's disease (CD) in remission do not exhibit an improvement in gut microbiota composition, which might trigger relapses. The present study investigated the dysbiosis and mucins production in CD patients during remission. We performed an analytical cross-sectional single center study, which recruited 18 CD patients and 18 healthy controls (CG) residing in the same home, meaning that all of the participants experienced the same environmental factors, with similar hygiene status, diet, pollution and other common lifestyle characteristics that may influence the composition of the gut microbiota. When compared to healthy controls, the CD patients exhibited lower microbial α-diversity (p = 0.047), a greater abundance of the Proteobacteria

SUBMITTER: Magro DO 

PROVIDER: S-EPMC6744406 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature