Ontology highlight
ABSTRACT:
SUBMITTER: Holdgaard SG
PROVIDER: S-EPMC6744468 | biostudies-literature | 2019 Sep
REPOSITORIES: biostudies-literature
Holdgaard Søs Grønbæk SG Cianfanelli Valentina V Pupo Emanuela E Lambrughi Matteo M Lubas Michal M Nielsen Julie C JC Eibes Susana S Maiani Emiliano E Harder Lea M LM Wesch Nicole N Foged Mads Møller MM Maeda Kenji K Nazio Francesca F de la Ballina Laura R LR Dötsch Volker V Brech Andreas A Frankel Lisa B LB Jäättelä Marja M Locatelli Franco F Barisic Marin M Andersen Jens S JS Bekker-Jensen Simon S Lund Anders H AH Rogov Vladimir V VV Papaleo Elena E Lanzetti Letizia L De Zio Daniela D Cecconi Francesco F
Nature communications 20190913 1
The centrosome is the master orchestrator of mitotic spindle formation and chromosome segregation in animal cells. Centrosome abnormalities are frequently observed in cancer, but little is known of their origin and about pathways affecting centrosome homeostasis. Here we show that autophagy preserves centrosome organization and stability through selective turnover of centriolar satellite components, a process we termed doryphagy. Autophagy targets the satellite organizer PCM1 by interacting with ...[more]