Selective autophagy maintains centrosome integrity and accurate mitosis by turnover of centriolar satellites.

ABSTRACT: The centrosome is the master orchestrator of mitotic spindle formation and chromosome segregation in animal cells. Centrosome abnormalities are frequently observed in cancer, but little is known of their origin and about pathways affecting centrosome homeostasis. Here we show that autophagy preserves centrosome organization and stability through selective turnover of centriolar satellite components, a process we termed doryphagy. Autophagy targets the satellite organizer PCM1 by interacting with GABARAPs via a C-terminal LIR motif. Accordingly, autophagy deficiency results in accumulation of large abnormal centriolar satellites and a resultant dysregulation of centrosome composition. These alterations have critical impact on centrosome stability and lead to mitotic centrosome fragmentation

SUBMITTER: Holdgaard SG 

PROVIDER: S-EPMC6744468 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature