Comparative study of excretory-secretory proteins released by Schistosoma mansoni-resistant, susceptible and naive Biomphalaria glabrata.

ABSTRACT:

Background

Schistosomiasis is a harmful neglected tropical disease caused by infection with Schistosoma spp., such as Schistosoma mansoni. Schistosoma must transition within a molluscan host to survive. Chemical analyses of schistosome-molluscan interactions indicate that host identification involves chemosensation, including naïve host preference. Proteomic technique advances enable sophisticated comparative analyses between infected and naïve snail host proteins. This study aimed to compare resistant, susceptible and naïve Biomphalaria glabrata snail-conditioned water (SCW) to identify potential attractants and deterrents.

Methods

Behavioural bioassays were performed on S. mansoni miracidia to compare the effects of susceptible, F1 resistant and naïve B. glabrata SCW. The

SUBMITTER: Fogarty CE 

PROVIDER: S-EPMC6744689 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature