A comprehensive assessment of demographic, environmental, and host genetic associations with gut microbiome diversity in healthy individuals.

ABSTRACT:

Background

The gut microbiome is an important determinant of human health. Its composition has been shown to be influenced by multiple environmental factors and likely by host genetic variation. In the framework of the Milieu Intérieur Consortium, a total of 1000 healthy individuals of western European ancestry, with a 1:1 sex ratio and evenly stratified across five decades of life (age 20-69), were recruited. We generated 16S ribosomal RNA profiles from stool samples for 858 participants. We investigated genetic and non-genetic factors that contribute to individual differences in fecal microbiome composition.

Results

Among 110 demographic, clinical, and environmental factors, 11 were identified as significantly correlated with α-diversity, ß-diversity, or abundance of speci

SUBMITTER: Scepanovic P 

PROVIDER: S-EPMC6744716 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature