A purely bioinformatic pipeline for the prediction of mammalian odorant receptor gene enhancers.

ABSTRACT:

Background

In most mammals, a vast array of genes coding for chemosensory receptors mediates olfaction. Odorant receptor (OR) genes generally constitute the largest multifamily (> 1100 intact members in the mouse). From the whole pool, each olfactory neuron expresses a single OR allele following poorly characterized mechanisms termed OR gene choice. OR genes are found in genomic aggregations known as clusters. Nearby enhancers, named elements, are crucial regulators of OR gene choice. Despite their importance, searching for new elements is burdensome. Other chemosensory receptor genes responsible for smell adhere to expression modalities resembling OR gene choice, and are arranged in genomic clusters - often with chromosomal linkage to OR genes. Still, no elements are known for the

SUBMITTER: Degl'Innocenti A 

PROVIDER: S-EPMC6744719 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature