Mechanistic basis of neonatal heart regeneration revealed by transcriptome and histone modification profiling.

ABSTRACT: The adult mammalian heart has limited capacity for regeneration following injury, whereas the neonatal heart can readily regenerate within a short period after birth. To uncover the molecular mechanisms underlying neonatal heart regeneration, we compared the transcriptomes and epigenomes of regenerative and nonregenerative mouse hearts over a 7-d time period following myocardial infarction injury. By integrating gene expression profiles with histone marks associated with active or repressed chromatin, we identified transcriptional programs underlying neonatal heart regeneration, and the blockade to regeneration in later life. Our results reveal a unique immune response in regenerative hearts and a retained embryonic cardiogenic gene program that is active during neonatal heart regeneration

SUBMITTER: Wang Z 

PROVIDER: S-EPMC6744882 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature