Integrative Molecular Characterization of Resistance to Neoadjuvant Chemoradiation in Rectal Cancer.

ABSTRACT: PURPOSE:Molecular properties associated with complete response or acquired resistance to concurrent chemotherapy and radiotherapy (CRT) are incompletely characterized.Experimental Design: We performed integrated whole-exome/transcriptome sequencing and immune infiltrate analysis on rectal adenocarcinoma tumors prior to neoadjuvant CRT (pre-CRT) and at time of resection (post-CRT) in 17 patients [8 complete/partial responders, 9 nonresponders (NR)]. RESULTS:CRT was not associated with increased tumor mutational burden or neoantigen load and did not alter the distribution of established somatic tumor mutations in rectal cancer. Concurrent KRAS/TP53 mutations (KP) associated with NR tumors and were enriched for an epithelial-mesenchymal transition transcriptional program. Furthermore, NR was

SUBMITTER: Kamran SC 

PROVIDER: S-EPMC6744983 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature