Pleiotropic Impact of DNA-PK in Cancer and Implications for Therapeutic Strategies.

ABSTRACT:

Purpose

DNA-dependent protein kinase catalytic subunit (DNA-PK) is a pleiotropic kinase involved in DNA repair and transcriptional regulation. DNA-PK is deregulated in selected cancer types and is strongly associated with poor outcome. The underlying mechanisms by which DNA-PK promotes aggressive tumor phenotypes are not well understood. Here, unbiased molecular investigation in clinically relevant tumor models reveals novel functions of DNA-PK in cancer.Experimental Design: DNA-PK function was modulated using both genetic and pharmacologic methods in a series of in vitro models, in vivo xenografts, and patient-derived explants (PDE), and the impact on the downstream signaling and cellular cancer phenotypes was discerned. Data obtained were used to develop nove

SUBMITTER: Dylgjeri E 

PROVIDER: S-EPMC6744985 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature