Dietary sulfur amino acid restriction upregulates DICER to confer beneficial effects.

ABSTRACT: OBJECTIVE:Dietary restriction (DR) improves health and prolongs lifespan in part by upregulating type III endoribonuclease DICER in adipose tissue. In this study, we aimed to specifically test which missing dietary component was responsible for DICER upregulation. METHODS:We performed a nutrient screen in mouse preadipocytes and validated the results in vivo using different kinds of dietary interventions in wild type or genetically modified mice and worms, also testing the requirement of DICER on the effects of the diets. RESULTS:We found that sulfur amino acid restriction (i.e., methionine or cysteine) is sufficient to increase Dicer mRNA expression in preadipocytes. Consistently, while DR increases DICER expression in adipose tissue of mice, this effect is blunted by supplementation of t

SUBMITTER: Guerra BA 

PROVIDER: S-EPMC6745493 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature