Molecular pathways of senescence regulate placental structure and function.

ABSTRACT: The placenta is an autonomous organ that maintains fetal growth and development. Its multinucleated syncytiotrophoblast layer, providing fetal nourishment during gestation, exhibits characteristics of cellular senescence. We show that in human placentas from pregnancies with intrauterine growth restriction, these characteristics are decreased. To elucidate the functions of pathways regulating senescence in syncytiotrophoblast, we used dynamic contrast-enhanced MRI in mice with attenuated senescence programs. This approach revealed an altered dynamics in placentas of p53^-/- , Cdkn2a^-/- , and Cdkn2a^-/- ;p53^-/- mice, accompanied by histopathological changes in placental labyrinths. Human primary syncytiotrophoblast upregulated senescence markers and

SUBMITTER: Gal H 

PROVIDER: S-EPMC6745498 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature