Comprehensive Characterization of Somatic Mutations Impacting lncRNA Expression for Pan-Cancer.

ABSTRACT: Somatic mutations have long been recognized as an important feature of cancer. However, analysis of somatic mutations, to date, has focused almost entirely on the protein coding regions of the genome. The potential roles of somatic mutations in human long noncoding RNAs (lncRNAs) are therefore largely unknown, particularly their functional significance across different cancer types. In this study, we characterized some lncRNAs whose expression was affected by somatic mutations (defined as MutLncs) and constructed global MutLnc landscapes across 17 cancer types by systematically integrating multiple levels of data. MutLncs were commonly downregulated and carried low mutation frequencies and non-silent mutations in most cancer types. Co-occurrence analysis in pan-cancer highlighted combined

SUBMITTER: Gao Y 

PROVIDER: S-EPMC6745513 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature