The relationship between pupil diameter and other measures of opioid withdrawal during naloxone precipitated withdrawal.

ABSTRACT:

Background

Understanding mechanisms of physiological opioid withdrawal symptoms can inform treatment strategies. This secondary analysis evaluated the association between mydriasis (dilated pupils), a commonly-assessed opioid withdrawal metric, with self- and observer-rated opioid withdrawal severity.

Method

Ninety-five participants with opioid physical dependence were stabilized with morphine before receiving an injection of the opioid antagonist naloxone to precipitate withdrawal. Pupil diameter, the Subjective Opiate Withdrawal Scale (SOWS), and the Clinical Opiate Withdrawal Scale (COWS) were collected at baseline and in 15-minute intervals for 120 min following naloxone administration. Pearson product-moment correlations and linear regressions characterized the relation

SUBMITTER: Bergeria CL 

PROVIDER: S-EPMC6745696 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature