Myceliophthora thermophila Xyr1 is predominantly involved in xylan degradation and xylose catabolism.

ABSTRACT:

Background

Myceliophthora thermophila is a thermophilic ascomycete fungus that is used as a producer of enzyme cocktails used in plant biomass saccharification. Further development of this species as an industrial enzyme factory requires a detailed understanding of its regulatory systems driving the production of plant biomass-degrading enzymes. In this study, we analyzed the function of MtXlr1, an ortholog of the (hemi-)cellulolytic regulator XlnR first identified in another industrially relevant fungus, Aspergillus niger.

Results

The Mtxlr1 gene was deleted and the resulting strain was compared to the wild type using growth profiling and transcriptomics. The deletion strain was unable to grow on xylan and d-xylose, but showed only a small growth reduct

SUBMITTER: Dos Santos Gomes AC 

PROVIDER: S-EPMC6745793 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature