Time patterns of recurrence and second primary tumors in a large cohort of patients treated for oral cavity cancer.

ABSTRACT:

Introduction

Routine follow-up after curative treatment of patients with oral squamous cell carcinoma (OSCC) is common practice considering the high risk of second primaries and recurrences (ie second events). Current guidelines advocate a follow-up period of at least 5 years. The recommendations are not evidence-based and benefits are unclear. This is even more so for follow-up after a second event. To facilitate the development of an evidence- and personalized follow-up program for OSCC, we investigated the course of time until the second and subsequent events and studied the risk factors related to these events.

Materials and methods

We retrospectively studied 594 OSCC patients treated with curative intent at the Head and Neck Cancer Unit of the Radboud University Medical

SUBMITTER: Brands MT 

PROVIDER: S-EPMC6745868 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature