Chimeric Antigen Receptor-T Cell Therapy: Practical Considerations for Implementation in Europe.

ABSTRACT: Chimeric antigen receptor (CAR)-T cell therapy is a new class of cellular immunotherapies that involves ex vivo genetic modification of T cells to incorporate an engineered CAR. After infusion into the patient, the CAR-expressing T cells recognize specific tumor targets and induce an immune response against them. The technology utilized is fundamentally different from previously available cancer treatments. Currently, most CAR-T cell therapies use autologous T cells. Tisagenlecleucel (formerly CTL019) is an anti-CD19 CAR-T cell therapy that was recently approved in the United States for the treatment of pediatric and young adult patients with relapsed/refractory B-cell acute lymphoblastic leukemia (B-ALL). Tisagenlecleucel has shown robust in vivo expansion and long-term persistence, clini

SUBMITTER: Buechner J 

PROVIDER: S-EPMC6745952 | biostudies-literature | 2018 Jan-Feb

REPOSITORIES: biostudies-literature