Novel Copper Complexes That Inhibit the Proteasome and Trigger Apoptosis in Triple-Negative Breast Cancer Cells.

ABSTRACT: Five innovative ternary copper(II) complexes [Cu(OH-PIP)(Phe)Cl](1), [Cu(OH-PIP)(Gly)(H₂O)]NO₃·2H₂O (2), [Cu(OH-PIP)(Ala)(Cl)]·H₂O (3), [Cu(OH-PIP)(Met)]PF₆·2H₂O (4), and [Cu(OH-PIP)(Gln)(H₂O)](Cl)·3H₂O (5) have been synthesized and characterized by infrared spectroscopy, elemental analysis, and single crystal X-ray diffraction analysis. X-ray crystallography indicates that all Cu atoms are five-coordinated in a square-pyramidal configuration. The complexes have been screened for cytotoxicity against human breast cancer cell lines MCF-7, MDA-MB-231, and CAL-51. The best anticancer activity is obtained with triple-negative breast cancer CAL-51 and MDA-MB-231 cell lines,

SUBMITTER: Li DD 

PROVIDER: S-EPMC6746097 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature