Immunophenotype of a Rat Model of Duchenne's Disease and Demonstration of Improved Muscle Strength After Anti-CD45RC Antibody Treatment.

ABSTRACT: Corticosteroids (CS) are standard therapy for the treatment of Duchenne's muscular dystrophy (DMD). Even though they decrease inflammation, they have limited efficacy and are associated with significant side effects. There is therefore the need for new protolerogenic treatments to replace CS. Dystrophin-deficient rats (Dmd^mdx ) closely resemble the pathological phenotype of DMD patients. We performed the first Immunophenotyping of Dmd^mdx rats and showed leukocyte infiltration in skeletal and cardiac muscles, which consisted mostly of macrophages and T cells including CD45RC^high T cells. Muscles of DMD patients also contain elevated CD45RC^high T cells. We treated Dmd^mdx rats with an anti-CD45RC

SUBMITTER: Ouisse LH 

PROVIDER: S-EPMC6746111 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature