Sex-specific relationship of cardiometabolic syndrome with lower cortical thickness.

ABSTRACT:

Objective

To investigate whether cardiometabolic factors were associated with age-related differences in cortical thickness in relation to sex.

Methods

In this cross-sectional study, we enrolled 1,322 cognitively normal elderly (≥65 years old) individuals (774 [58.5%] men, 548 [41.5%] women). We measured cortical thickness using a surface-based analysis. We analyzed the associations of cardiometabolic risk factors with cortical thickness using multivariate linear regression models after adjusting for possible confounders and interactions with age.

Result

Among women, hypertension (β = -1.119 to -0.024, p < 0.05) and diabetes mellitus (β = -0.920, p = 0.03) were independently associated with lower mean cortical thickness. In addition, there was an interac

SUBMITTER: Kim SE 

PROVIDER: S-EPMC6746207 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature