Community-informed connectomics of the thalamocortical system in generalized epilepsy.

ABSTRACT:

Objective

To study the intrinsic organization of the thalamocortical circuitry in patients with generalized epilepsy with tonic-clonic seizures (GTCS) via resting-state fMRI (rs-fMRI) connectome analysis and to evaluate its relation to drug response.

Methods

In a prospectively followed-up sample of 41 patients and 27 healthy controls, we obtained rs-fMRI and structural MRI. After 1 year of follow-up, 27 patients were classified as seizure-free and 14 as drug-resistant. We examined connectivity within and between resting-state communities in cortical and thalamic subregions. In addition to comparing patients to controls, we examined associations with seizure control. We assessed reproducibility in an independent cohort of 21 patients.

Results

Compared to controls, pati

SUBMITTER: Wang Z 

PROVIDER: S-EPMC6746209 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature