Palmitoylation by Multiple DHHC Enzymes Enhances Dopamine Transporter Function and Stability.

ABSTRACT: The dopamine transporter (DAT) is a plasma membrane protein that mediates the reuptake of extracellular dopamine (DA) and controls the spatiotemporal dynamics of dopaminergic neurotransmission. The transporter is subject to fine control that tailors clearance of transmitter to physiological demands, and dysregulation of reuptake induced by psychostimulant drugs, transporter polymorphisms, and signaling defects may impact transmitter tone in disease states. We previously demonstrated that DAT undergoes complex regulation by palmitoylation, with acute inhibition of the modification leading to rapid reduction of transport activity and sustained inhibition of the modification leading to transporter degradation and reduced expression. Here, to examine mechanisms and outcomes related to increase

SUBMITTER: Bolland DE 

PROVIDER: S-EPMC6746250 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature