CD13 deficiency leads to increased oxidative stress and larger atherosclerotic lesions.

ABSTRACT:

Background and aims

Atherosclerosis is an inflammatory cardiovascular disorder characterized by accumulation of lipid-loaded macrophages in the intima. Prolonged accumulation leads to apoptosis of macrophages and eventually to progression of lesion development. Prevention of macrophage accumulation within the intima has been shown to reduce lesion formation. Since CD13 mediates trafficking of macrophages to sites of injury and repair, we tested the role of CD13 in atherosclerosis.

Methods

CD13^+/+Ldlr^-/- and CD13^-/-Ldlr^-/- (low density lipoprotein receptor) mice were fed basal or high fat diet (HFD) for 9, 12 and 15 weeks. Mice were euthanized and aortic roots along with innominate arteries were analyzed for atherosclerotic lesions.

SUBMITTER: Devarakonda CV 

PROVIDER: S-EPMC6746312 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature