Deciphering the BSE-type specific cell and tissue tropisms of atypical (H and L) and classical BSE.

ABSTRACT: After the discovery of two atypical bovine spongiform encephalopathy (BSE) forms in France and Italy designated H- and L-BSE, the question arose whether these new forms differed from classical BSE (C-BSE) in their pathogenesis. Samples collected from cattle in the clinical stage of BSE during an intracranial challenge study with L- and H-BSE were analysed using biochemical and histological methods as well as in a transgenic mouse bioassay. Our results generally confirmed what had been described for C-BSE to be true also for both atypical BSE forms, namely the restriction of the pathological prion protein (PrP^Sc) and BSE infectivity to the nervous system. However, analysis of samples collected under identical conditions from both atypical H- and L-BSE forms allowed us a more prec

SUBMITTER: Balkema-Buschmann A 

PROVIDER: S-EPMC6746549 | biostudies-literature | 2019 Jan

REPOSITORIES: biostudies-literature