A rule-based method for predicting the electrical activation of the heart with cardiac resynchronization therapy from non-invasive clinical data.

ABSTRACT:

Background

Cardiac Resynchronization Therapy (CRT) is one of the few effective treatments for heart failure patients with ventricular dyssynchrony. The pacing location of the left ventricle is indicated as a determinant of CRT outcome.

Objective

Patient specific computational models allow the activation pattern following CRT implant to be predicted and this may be used to optimize CRT lead placement.

Methods

In this study, the effects of heterogeneous cardiac substrate (scar, fast endocardial conduction, slow septal conduction, functional block) on accurately predicting the electrical activation of the LV epicardium were tested to determine the minimal detail required to create a rule based model of cardiac electrophysiology. Non-invasive clinical data (CT or CMR imag

SUBMITTER: Lee AWC 

PROVIDER: S-EPMC6746621 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature