MiRNAs in depression vulnerability and resilience: novel targets for preventive strategies.

ABSTRACT: The exposure to stressful experiences during the prenatal period and through the first years of life is known to affect the brain developmental trajectories, leading to an enhanced vulnerability for the development of several psychiatric disorders later in life. However, not all the subjects exposed to the same stressful experience develop a pathologic condition, as some of them, activating coping strategies, become more resilient. The disclosure of mechanisms associated with stress vulnerability or resilience may allow the identification of novel biological processes and potential molecules that, if properly targeted, may prevent susceptibility or potentiate resilience. Over the last years, miRNAs have been proposed as one of the epigenetic mechanisms mediating the long-lasting effects of

SUBMITTER: Lopizzo N 

PROVIDER: S-EPMC6746676 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature