Clinical importance of potassium intake and molecular mechanism of potassium regulation.

ABSTRACT:

Introduction

Potassium (K⁺) intake is intrinsically linked to blood pressure. High-K⁺ intake decreases hypertension and associated lower mortality. On the other hand, hyperkalemia causes sudden death with fatal cardiac arrhythmia and is also related to higher mortality. Renal sodium (Na⁺)-chloride (Cl^‒) cotransporter (NCC), expressed in the distal convoluted tubule, is a key molecule in regulating urinary K⁺ excretion. K⁺ intake affects the activity of the NCC, which is related to salt-sensitive hypertension. A K⁺-restrictive diet activates NCC, and K⁺ loading suppresses NCC. Hyperpolarization caused by decreased extracellular K⁺ concentration ([K⁺]_ex) increases

SUBMITTER: Nomura N 

PROVIDER: S-EPMC6746677 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature