Autoregulation assessment by direct visualisation of pial arterial blood flow in the piglet brain.

ABSTRACT: Impairment of cerebrovascular autoregulation (CAR) is common after brain injury, although the pathophysiology remains elusive. The mechanisms of vascular dysregulation, their impact on brain function, and potential therapeutic implications are still incompletely understood. Clinical assessment of CAR remains challenging. Observational studies suggest that CAR impairment is associated with worse outcomes, and that optimization of cerebral blood flow (CBF) by individual arterial blood pressure (ABP) targets could potentially improve outcome. We present a porcine closed cranial window model that measures the hemodynamic response of pial arterioles, the main site of CBF control, based on changes in their diameter and red blood cell velocity. This quantitative direct CAR assessment is compared

SUBMITTER: Klein SP 

PROVIDER: S-EPMC6746693 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature