Distinct gene expression profiles between primary breast cancers and brain metastases from pair-matched samples.

ABSTRACT: Our objectives were to determine whether clinic-pathological markers and immune-related gene signatures in breast cancer exhibit any change upon brain metastasis and whether previously reported genes significantly associated with brain metastases and the epithelial-mesenchymal transition (EMT) were reproducible and consistent in our dataset. Sixteen pair-matched samples from primary breast cancers and brain metastases diagnosed were collected from the Japan Clinical Oncology Group Breast Cancer Study Group. Gene expression profiles for immune-, brain metastases-, and EMT-related genes were compared between primary breast cancers and brain metastases. Potential therapeutic target genes of 41 FDA-approved or under-investigation agents for brain metastases were explored. Immune-related signat

SUBMITTER: Iwamoto T 

PROVIDER: S-EPMC6746866 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature