Antibody-Functionalized MoS₂ Nanosheets for Targeted Photothermal Therapy of Staphylococcus aureus Focal Infection.

ABSTRACT: Bacterial biofilm-related diseases cause serious hazard to public health and bring great challenge to the traditional antibiotic treatment. Photothermal therapy (PTT) has been recognized as a promising alternative solution. However, the therapeutic efficacy of PTT is often compromised by the collateral damage to normal tissues due to the lack of bacteria-targeting capability. Here, a Staphylococcus aureus (S. aureus)-targeted PTT nanoagent is prepared based on antibody (anti-protein A IgG), polydopamine (PDA), and PEG-SH (thiolated poly (ethylene glycol)) functionalized MoS₂ nanosheets (MoS₂@PDA-PEG/IgG NSs, MPPI NSs). The PDA was used as bio-nano interface to facilitate the covalent conjugation of antibody and PEG-SH onto the surface of MoS₂

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC6746923 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature