Vaginal Microbiome Signature Is Associated With Spontaneous Preterm Delivery.

ABSTRACT: Background: Preterm delivery (PTD) represents an important public health and therapeutic challenge. Despite the reported link between the composition of vaginal microbiome and PTD, previous studies were inconsistent in their conclusions and utilized non-uniform designs. We performed an independent case-control study carried out on the Slovenian population, where we re-evaluated the role of the vaginal microbiome in PTD. Methods: Vaginal microbiomes of pregnant women who delivered preterm were compared to those delivered at term to examine differences in the microbial richness, diversity, and differential abundance of specific taxa. We obtained vaginal swab samples from 155 Caucasian women who were classified as either term (≥38^0/7 weeks, n = 107) or preterm

SUBMITTER: Hocevar K 

PROVIDER: S-EPMC6746969 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature