Opioid Addiction, Genetic Susceptibility, and Medical Treatments: A Review.

ABSTRACT: Opioid addiction is a chronic and complex disease characterized by relapse and remission. In the past decade, the opioid epidemic or opioid crisis in the United States has raised public awareness. Methadone, buprenorphine, and naloxone have proven their effectiveness in treating addicted individuals, and each of them has different effects on different opioid receptors. Classic and molecular genetic research has provided valuable information and revealed the possible mechanism of individual differences in vulnerability for opioid addiction. The polygenic risk score based on the results of a genome-wide association study (GWAS) may be a promising tool to evaluate the association between phenotypes and genetic markers across the entire genome. A novel gene editing approach, clustered, regular

SUBMITTER: Wang SC 

PROVIDER: S-EPMC6747085 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature