Robustness of Clonogenic Assays as a Biomarker for Cancer Cell Radiosensitivity.

ABSTRACT: Photon radiation therapy is a major curative treatment for cancer. However, the lack of robust predictive biomarkers for radiosensitivity precludes personalized radiation therapy. Clonogenic assays are the gold standard method for measuring the radiosensitivity of cancer cells. Although a large number of publications describe the use of clonogenic assays to measure cancer cell radiosensitivity, the robustness of results from different studies is unclear. To address this, we conducted a comprehensive detailed literature search of 256 common cancer cell lines and identified the eight cell lines most-frequently examined for photon sensitivity using clonogenic assays. Survival endpoints and experimental parameters from all 620 relevant experiments were compiled and analyzed. We found that the

SUBMITTER: Matsui T 

PROVIDER: S-EPMC6747107 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature