Association of Obesity with DNA Methylation Age Acceleration in African American Mothers from the InterGEN Study.

ABSTRACT: African American women are affected by earlier onset of age-associated health deteriorations and obesity disproportionally, but little is known about the mechanism linking body mass index (BMI) and biological aging among this population. DNA methylation age acceleration (DNAm AA), measuring the difference between DNA methylation age and chronological age, is a novel biomarker of the biological aging process, and predicts aging-related disease outcomes. The present study estimated cross-tissue DNA methylation age acceleration using saliva samples from 232 African American mothers. Cross-sectional regression analyses were performed to assess the association of BMI with DNAm AA. The average chronological age and DNA methylation age were 31.67 years, and 28.79 years, respectively. After adjust

SUBMITTER: Li C 

PROVIDER: S-EPMC6747309 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature